What would you do if your mother moved in with you and just wouldn't leave? When NOAH COOPER, 29, is fired from his job as a therapist, he thinks his day can't possibly get worse. When he arrives home his already full house gets even crazier when MARILYN, Noah's overbearing mother arrives with her five dogs in tow needing a place to stay. Comedy ensues as Noah learns to deal with the pressures of finding a job, a wife who desperately wants a baby, and worst of all a mother who won't quit smothering!

Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame (appearing in 600 newspapers in over 20 countries) to big screen stardom in this family comedy event. A suburban family moves to a new neighborhood in Orange County, California with their large yet lovable Great Dane, who has a tendency to wreak havoc in his own oblivious way. But its not all living large for the Duke, who finds that fitting in with his new four-legged friends - and a potential romantic interest - isn't always easy for a super-sized teenage dog. Owen Wilson gives the beloved Great Dane his voice in the film, which also features the voices of Fergie, George Lopez, Emma Stone and Kiefer Sutherland.